Etiology of colorectal cancer (C18–20) in Central and South America
نویسندگان
چکیده
Colorectal cancer is a heterogeneous disease that arises from multiple tumorigenic pathways [1–6]. Colon and rectal adenocarcinomas are the result of a stepwise progression from normal tissue to dysplastic epithelium to carcinoma – referred to as the adenoma–carcinoma sequence – which is accompanied by multiple genetic alterations including oncogenes, the activation and inactivation of tumour suppressor genes, and mismatch repair genes [6].
منابع مشابه
اپیدمیولوژی سرطان کولورکتال: میزان بروز، مرگ و میر، بقاء و عوامل خطر آن
Abstract Background: Colorectal cancer is one of the most common cancers of gastrointestinal tract in Iran and the other parts of the world. Colorectal cancer is the fourth leading cause of cancer death in throughout the world. Almost every year recognizes one million new cases of colorectal cancer that nearly half a million of them die due to this disease. Materials and methods: In this ...
متن کاملmiR-506 inhibits cell proliferation and invasion by targeting TET family in colorectal cancer
Objective(s): Ten-eleven translocation (TET) family members have been shown to be involved in the development of many tumors. However, the biological role of the TET family and its mechanism of action in colorectal carcinogenesis and progression remain poorly understood. Materials and Methods:We measured the expression levels of TET family members in colorectal cancer (CRC) specimens, in the c...
متن کاملSpatial Analysis of Factors Affecting Colorectal Cancer Using the Model of Geographical Weight Regression in Iran
Background and Objectives: The incidence of colorectal cancer has increased significantly in Iran in recent decades. The pattern of occurrence varies in different populations. A study was conducted to perform a spatial analysis of colorectal cancer and some of its risk factors in Iran using GIS. Methods: The data of this descriptive-analytic study included colorectal cancer incidence as a d...
متن کاملUsing 5-fluorouracil-encored plga nanoparticles for the treatment of colorectal cancer: the in-vitro characterization and cytotoxicity studies
Objective(s): Colorectal cancer (CRC) is a prevalent cancer worldwide. The present study aimed to synthesize and investigate the potential of wheat germ agglutinin (WGA) conjugated with polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) incorporating 5-fluorouracil (5-FU). Materials and Methods: The NPs were investigated in terms of various characteristics, such as the particle size, ...
متن کاملCTGF and MLH1 Gene Expression Levels in Colorectal Cancer Tumor Tissues and Adjacent Normal Tissues in Patients in Golestan Province
Background and purpose: Colorectal cancer is the third most common type of cancer in terms of incidence and the second most common cause of cancer-related death worldwide. The aim of this study was to investigate the expression of CTGF and MLH1 gene in colorectal cancer tumor tissues and adjacent normal tissues in patients in Golestan province. Materials and methods: In this experimental study...
متن کامل